Blastic lymphocytes, immunoglobulin synthesizing cells and Tγ lymphocytes in rheumatoid synovial membrane
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چکیده
منابع مشابه
Spontaneous and induced immunoglobulin secretion by synovial fluid B lymphocytes in rheumatoid arthritis.
The functional properties of B lymphocytes in synovial fluid (SF) from patients with rheumatoid arthritis (RA) were analysed by means of a reverse haemolytic plaque forming cell (PFC) assay. SF mononuclear cells spontaneously secreted IgG, but little IgM or IgA. The SF cells failed to respond to the polyclonal B cell activators pokeweed mitogen (PWM) and Epstein-Barr virus. However, SF B cells ...
متن کاملStudies on synovial fluid lymphocytes in rheumatoid arthritis.
Rheumatoid arthritis (RA) is a systemic disease in which the major lesion is a chronic inflammation of the synovial membrane, with a characteristic though not pathognomonic histology. Rheumatoid activity in the synovial membrane may lead to the production of an increased amount of synovial fluid which in active cases is often richly cellular with polymorphs, monocyte-like cells, or lymphocytes ...
متن کاملCytotoxic activity of rheumatoid and normal lymphocytes against allogeneic and autologous synovial cells in vitro.
The possibility that lymphocytes from patients with rheumatoid arthritis (RA) might be sensitized to RA synovial cell antigens was investigated with a 51Cr release cytotoxicity assay. Peripheral blood lymphocytes from rheumatoid and normal donors were tested for cytotoxic activity against their own synovial cells and against allogeneic rheumatoid and nonrhemuatoid synovial cells. In the allogen...
متن کاملIn vitro synthesis of immunoglobulin by rheumatoid synovial membrane.
A technique for the in vitro culture of rheumatoid synovial tissue with (14)C-amino acids and isolation and quantitation of the newly synthesized immunoglobulins has been developed. This technique has been used to compare immunoglobulin synthesis of 12 rheumatoid synovia with that of synovia from nonarthritic patients and with that of normal human lymph nodes and spleen. In addition, the spleen...
متن کاملExpression of CD44 on rheumatoid synovial fluid lymphocytes.
OBJECTIVES To investigate the involvement of the adhesion molecule CD44 in the homing of lymphocytes to synovial tissue, by examining the density of expression and molecular mass of CD44 on rheumatoid synovial fluid lymphocytes. METHODS Twenty patients with rheumatoid arthritis were studied. Peripheral blood and synovial fluid lymphocytes were isolated by Ficoll-Hypaque sedimentation. CD44 ex...
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ژورنال
عنوان ژورنال: Ensho
سال: 1981
ISSN: 0389-4290,1884-4006
DOI: 10.2492/jsir1981.2.4_421